Phenotypes Associated with This Genotype

Genotype
MGI:2654536

• Allelic Composition: Spib^tm1Mcs/Spib^tm1Mcs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell proliferation ( J:88257 )

• IgM cross-linking or pervanadate/H202 stimulation yields less than normal levels of tyrosine phosphorylation and IgM cross-linking also yields less calcium mobilization than normal

abnormal immature B cell morphology ( J:88257 )

• splenic B cells have 2 to 4 fold higher surface expression of IgM and B cells also express high levels of surface CD19 and CD21

immune system

decreased B cell proliferation ( J:88257 )

• IgM cross-linking or pervanadate/H202 stimulation yields less than normal levels of tyrosine phosphorylation and IgM cross-linking also yields less calcium mobilization than normal

abnormal immature B cell morphology ( J:88257 )

• splenic B cells have 2 to 4 fold higher surface expression of IgM and B cells also express high levels of surface CD19 and CD21

cellular

decreased B cell proliferation ( J:88257 )

• IgM cross-linking or pervanadate/H202 stimulation yields less than normal levels of tyrosine phosphorylation and IgM cross-linking also yields less calcium mobilization than normal