Analysis Tools
mortality/aging
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• MCMV-treated
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• mice infected with 5 pfu MHV die within 48 hours while wild-type mice survive
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• 8 of 18 mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) die between days 4 and 7 post infection
• 50% of mice inoculated with the rodent brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection
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immune system
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• mice infected with the Urbani strain of severe acute respiratory syndrome coronavirus (SARS-CoV) or a recombinant isogenic mouse-adapted SARS-CoV (rMA15) that contains six virulence modifying mutations show no increase in susceptibility, pathogenesis, or histological outcomes to infection compared to wild-type controls
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• levels of IgG1a, IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus
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• there is 50% less actively proliferating NK cells in the spleen after MCMV infection compared to controls
(J:79552)
• NK cells in vivo make much about a fifth less IFN-gamma in response to injections of the TLR9 agonist CpG
(J:139001)
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• NK cells from MCMV-infected mice have 10-fold less cytotoxicity than wild-type NK cells
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• in mutant dendritic cells, induction of MHC and costimulatory molecules does not occur in response poly(I:C), in contrast to wild-type cells; LPS or CpG-dependent induction of MHC I and costimulatory molecules is also suppressed
• Ifn beta stimulation of dendritic cells elicits a significantly lower response in mutant cells than in wild-type
• amplification of dendritic signaling is suppressed in mutant dendritic cells stimulated with poly(I:C); RelA activation is suppressed
• induction of MHC and costimulatory molecules is abolished in dendritic cells upon infection with Newcastle disease virus (NDC)
• maturation of dendritic cells is impaired when stimulated by poly(I:C), LPS or NDV, but migration in T cell zone of spleen is not affected
• stimulatory activity of CD4+ and CD8+ T cells by poly(I:C) is impaired in poly(I:C)-stimulated mutant dendritic cells; stimulatory activity of CD8+ T cells is impaired in the LPS- or CpG-stimulated dendritic cells to a lesser extent than in poly(I:C)-stimulated cells
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• upon viral infection, interferon alpha induction is normal initially, but in later phases does not reach wild-type levels
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• in mutant dendritic cells, induction of MHC and costimulatory molecules does not occur in response poly(I:C), in contrast to wild-type cells; LPS or CpG-dependent induction of MHC I and costimulatory molecules is also suppressed
• MHC I induction is severely impaired in response to all three stimuli
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• mice are 100-fold more susceptible to murine cytomegalovirus, Smith strain (MCMV)
• mice infected with herpes simplex type 2 (HSV-2)
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• MCMV-treated
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• increased susceptibility to Ectromelia virus
• 100% mortality by day 6-12 after primary infection infection
• elevated virus titers in all organs tested after primary infection but much improved after secondary infections
• survive secondary infections
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• mice show increased susceptibility to infection with murine hepatitis virus (MHV) A59 (a coronavirus)
• plasmacytoid dendritic cells (pDCs) are more susceptible to MHV infection than wild-type pDCs
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• mice infected with 5 pfu MHV die within 48 hours while wild-type mice survive
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• mice inoculated intranasally with the attenuated Edmonston measles virus (MV-Edm)
• 8 of 18 mice inoculated intracerebrally with MV-Edm die between days 4 and 7 post infection and show signs of neurological disease including initial hyperactivity followed by awkward gait, lethargy, lack of mobility, and death
• susceptibility to MV-Edm infection is more pronounced if less virus is inoculated
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• 8 of 18 mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) die between days 4 and 7 post infection
• 50% of mice inoculated with the rodent brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection
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• increased susceptibility of encephalomyocarditis virus
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liver/biliary system
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• MHV-infected mice develop an acute hemorrhagic liver disease with massive hepatocyte necrosis
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vision/eye
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• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
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cardiovascular system
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• MHV-infected mice develop an acute hemorrhagic liver disease with massive hepatocyte necrosis
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• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice
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hematopoietic system
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• levels of IgG1a, IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus
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• there is 50% less actively proliferating NK cells in the spleen after MCMV infection compared to controls
(J:79552)
• NK cells in vivo make much about a fifth less IFN-gamma in response to injections of the TLR9 agonist CpG
(J:139001)
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• NK cells from MCMV-infected mice have 10-fold less cytotoxicity than wild-type NK cells
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homeostasis/metabolism
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• MHV-infected mice show rapidly rising liver enzyme values in serum
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behavior/neurological
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• mice inoculated intracerebrally with MV-Edm show initial hyperactivity that is followed by awkward gait and lethargy
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• mice inoculated intracerebrally with MV-Edm show initial hyperactivity followed by awkward gait and lack of mobility
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• mice inoculated intracerebrally with MV-Edm show initial hyperactivity following infection
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