Phenotypes Associated with This Genotype

Genotype
MGI:2654374

• Allelic Composition: Tg(Myh6-Gnaq)25Gwd/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:41949 )

thick interventricular septum ( J:144736 )

• mice exhibit an increased interventricular septal thickness compared to in wild-type mice

cardiac hypertrophy ( J:41949 )

• heart weight is 25% greater than in controls and cardiomyocyte dimensions are larger

abnormal heart left ventricle morphology ( J:144736 )

• mice exhibit an increase in left ventricle posterior wall thickness compared to in wild-type mice

heart left ventricle hypertrophy ( J:41949 )

decreased cardiac muscle contractility ( J:41949 , J:144736 )

• fractional shortening is depressed (J:41949)

• the normal beta-adrenergic (via dobutamine) augmentation of cardiac contractility and relaxation is absent in mutants (J:41949)

decreased heart left ventricle muscle contractility ( J:41949 )

• reduction in contractility of left ventricle

increased left ventricle diastolic pressure ( J:144736 )

decreased heart rate ( J:41949 )

• heart rate is slower during conscious blood pressure measurements and anesthetized echocardiographic studies

decreased systemic arterial systolic blood pressure ( J:41949 )

muscle

increased myocardial fiber size ( J:41949 )

heart left ventricle hypertrophy ( J:41949 )

decreased cardiac muscle contractility ( J:41949 , J:144736 )

• fractional shortening is depressed (J:41949)

• the normal beta-adrenergic (via dobutamine) augmentation of cardiac contractility and relaxation is absent in mutants (J:41949)

decreased heart left ventricle muscle contractility ( J:41949 )

• reduction in contractility of left ventricle

growth/size/body

cardiac hypertrophy ( J:41949 )

• heart weight is 25% greater than in controls and cardiomyocyte dimensions are larger

heart left ventricle hypertrophy ( J:41949 )