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Phenotypes Associated with This Genotype
Genotype
MGI:2654364
Allelic
Composition		 S100a9tm1Hogg/S100a9tm1Hogg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
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Mouse lines carrying:
S100a9tm1Hogg mutation (2 available); any S100a9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:82513 )
N
• normal response to inflammatory stimulus
abnormal neutrophil morphology ( J:82513 )
• density of neutrophils is greater than in wild-type
abnormal neutrophil physiology ( J:82513 )
• basal level of intracellular calcium is consistently higher in mutant neutrophils than in wild-type
• calcium response of neutrophils is significantly diminished when stimulated with low levels of the chemokine, MIP-2

hematopoietic system
abnormal neutrophil morphology ( J:82513 )
• density of neutrophils is greater than in wild-type
abnormal neutrophil physiology ( J:82513 )
• basal level of intracellular calcium is consistently higher in mutant neutrophils than in wild-type
• calcium response of neutrophils is significantly diminished when stimulated with low levels of the chemokine, MIP-2

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory