Phenotypes Associated with This Genotype

Genotype
MGI:2654213

• Allelic Composition: Maf^Ofl/Maf^Ofl
• Genetic Background: either: 102/ElH or C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:82475 )

• small animals die at various ages within a few weeks of birth

neonatal lethality, incomplete penetrance ( J:82475 )

• the majority of mice born fail to feed and die or disappear within 24 hours

• some mice survive to various ages

behavior/neurological

tremors ( J:82475 )

• mice surviving to at least 2 weeks of age possessed a tremor

growth/size/body

decreased body size ( J:82475 )

• mice that feed and survive to at least 2 weeks of age, are small

renal/urinary system

increased urine glucose level ( J:82475 )

• animals test positive for urine glucose from about 4 weeks of age

• urine glucose levels increase with age

• blood glucose and insulin levels are normal

abnormal kidney morphology ( J:82475 )

• kidneys abnormalities vary in severity, but appeared grossly abnormal, pale in color and with lumpy surface

tubular nephritis ( J:82475 )

• tubular nephritis is seen in mutants that survive beyond one month

dilated renal tubule ( J:82475 )

vision/eye

small pupil ( J:82475 )

abnormal lens induction ( J:82475 )

• lenses remain undifferentiated even in mice surviving beyond 2 weeks of age

microphthalmia ( J:82475 )

homeostasis/metabolism

increased urine glucose level ( J:82475 )

• animals test positive for urine glucose from about 4 weeks of age

• urine glucose levels increase with age

• blood glucose and insulin levels are normal

immune system

tubular nephritis ( J:82475 )

• tubular nephritis is seen in mutants that survive beyond one month