Phenotypes for Brca2 MGI:2653931 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Brca2^tm1Hst/Brca2^tm2Hst
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Hst mutation (0 available); any Brca2 mutation (133 available)
Brca2^tm2Hst mutation (0 available); any Brca2 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

early cellular replicative senescence ( J:82434 )

• primary MEFs senesce prematurely in culture

chromosomal instability ( J:82434 )

• primary MEFs have higher numbers of chromosomal aberrations even at passage 2 and accumulate further aberrations more rapidly than wild-type MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24