Phenotypes Associated with This Genotype

Genotype
MGI:2653911

• Allelic Composition: Il13ra2^tm1Gru/Il13ra2^tm1Gru
• Genetic Background: C.Cg-Il13ra2^tm1Gru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:82376 )

♀ • significantly higher frequencies of bone marrow macrophage progenitors per femur as shown by increased macrophage colony formation

♀ • however, frequency of immature bone marrow erythroid precursors (TER-119), splenic colony formation, and peripheral blood lymphocyte populations are normal

decreased erythroid progenitor cell number ( J:82376 )

♀ • frequencies of immature erythroid (BFU-E) progenitors per femur are significantly reduced

increased IgA level ( J:82376 )

♀ • significantly increased serum IgA levels

increased IgE level ( J:82376 )

♀ • significantly increased serum IgE levels

increased IgG2a level ( J:82376 )

♀ • significantly increased serum IgG2a levels

increased IgG2b level ( J:82376 )

♀ • significantly increased serum IgG2b levels

abnormal macrophage physiology ( J:82376 )

♀

immune system

increased IgA level ( J:82376 )

♀ • significantly increased serum IgA levels

increased IgE level ( J:82376 )

♀ • significantly increased serum IgE levels

increased IgG2a level ( J:82376 )

♀ • significantly increased serum IgG2a levels

increased IgG2b level ( J:82376 )

♀ • significantly increased serum IgG2b levels

abnormal macrophage physiology ( J:82376 )

♀

decreased circulating interleukin-13 level ( J:82376 )

♀ • serum interleukin-13 levels are significantly reduced or absent

♀ • in contrast, lung and liver interleukin-13 levels are increased

increased interferon-gamma secretion ( J:82376 )

♀ • ~2-fold increase in interferon gamma production from mutant spleen cells in response to activation with anti-CD3

increased interleukin-10 secretion ( J:82376 )

♀ • significantly increased IL-10 production from mutant spleen cells in response to activation with anti-CD3

decreased interleukin-4 secretion ( J:82376 )

♀ • significantly reduced IL-4 production from mutant spleen cells in response to activation with anti-CD3

decreased susceptibility to endotoxin shock ( J:82376 )

♀ • decreased in vitro sensitivity of resident peritoneal macrophages to LPS, as determined by NO production

homeostasis/metabolism

decreased circulating interleukin-13 level ( J:82376 )

♀ • serum interleukin-13 levels are significantly reduced or absent

♀ • in contrast, lung and liver interleukin-13 levels are increased