Phenotypes Associated with This Genotype

Genotype
MGI:2653710

• Allelic Composition: Vpreb1a^tm1Ilm/Vpreb1a^tm1Ilm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:53512 )

N • allelic exclusion of IgH occurs normally

N • good antibody response to T cell dependent antigens

arrested B cell differentiation ( J:53512 )

• accumulation of cells at the pre-BI stage, indicating a partial block at the transition from pre-BI to pre-BII cells (into the pre-BCR stage)

abnormal pre-B cell morphology ( J:53512 )

• percentage of pre-BI cells is increased and the percentage of pre-BII and immature B cells is slightly decreased

hematopoietic system

arrested B cell differentiation ( J:53512 )

• accumulation of cells at the pre-BI stage, indicating a partial block at the transition from pre-BI to pre-BII cells (into the pre-BCR stage)

abnormal pre-B cell morphology ( J:53512 )

• percentage of pre-BI cells is increased and the percentage of pre-BII and immature B cells is slightly decreased