Phenotypes Associated with This Genotype

Genotype
MGI:2653687

• Allelic Composition: Vps26a^Tg(HB58)Cos/Vps26a^Tg(HB58)Cos
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:11387 )

• homozygous mutant embryos are usually resorbed by E11.5

growth/size/body

embryonic growth retardation ( J:11387 )

• Background Sensitivity: the size and extent of development attained by mutant embryos on a congenic C57BL/6J genetic background are somewhat reduced relative to those on a mixed genetic background

• at E9.5, homozygous mutant embryos of a mixed genetic background reach the size and complexity of E8.5 wild-type embryos

• however, a variety of structures derived from ectoderm (neural plate), mesoderm (cardiac muscles, somites, red blood cells) and definitive endoderm (foregut) as well as several extraembryonic tissues (yolk sac, amnion, allantois, trophoblast) are successfully formed

embryo

abnormal ectoderm development ( J:11387 )

• at E7.5, homozygous mutant embryos display a small, underdeveloped ectoderm

embryonic growth arrest ( J:11387 )

• although developmentally normal until E6.5, homozygous mutant embryos cease to grow and differentiate at E10.5 or thereafter

embryonic growth retardation ( J:11387 )

• Background Sensitivity: the size and extent of development attained by mutant embryos on a congenic C57BL/6J genetic background are somewhat reduced relative to those on a mixed genetic background

• at E9.5, homozygous mutant embryos of a mixed genetic background reach the size and complexity of E8.5 wild-type embryos

• however, a variety of structures derived from ectoderm (neural plate), mesoderm (cardiac muscles, somites, red blood cells) and definitive endoderm (foregut) as well as several extraembryonic tissues (yolk sac, amnion, allantois, trophoblast) are successfully formed

abnormal embryonic tissue morphology ( J:11387 )

incomplete somite formation ( J:11387 )

• at E9.5, some homozygous mutant embryos fail to exhibit somite formation

abnormal extraembryonic tissue morphology ( J:11387 )

• at E7.5, homozygous mutant embryos frequently exhibit abnormal proliferation and folding of the extraembryonic membranes

abnormal chorioallantoic fusion ( J:11387 )

• at E9.5, many homozygous mutant embryos display a large, spherical allantois, suggesting abnormal chorioallantoic fusion