Phenotypes Associated with This Genotype

Genotype
MGI:2653583

• Allelic Composition: Tg(Mx1-IL11)1Tku/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

increased femur compact bone thickness ( J:80706 )

• increase in cortical bone thickness at the diaphysis of femurs at 10 weeks of age

• cortical bone thickness of femurs increases in mutants but decreases in wild-type mice with aging

skeleton

increased femur compact bone thickness ( J:80706 )

• increase in cortical bone thickness at the diaphysis of femurs at 10 weeks of age

• cortical bone thickness of femurs increases in mutants but decreases in wild-type mice with aging

increased bone mineral density of femur ( J:80706 )

• bone mineral density of femurs increases in mutants but decreases in wild-type with advancing age

increased trabecular bone volume ( J:80706 )

• increase in trabecular bone volume

increased bone mass ( J:80706 )

• progressive increase in bone mass

abnormal bone ossification ( J:80706 )

• significant increase in mineral apposition rates, resulting in increased bone formation rates with no change in bone resorption

increased bone strength ( J:80706 )

• bone strength is increased at 52 weeks of age compared to wild-type