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Phenotypes Associated with This Genotype
Genotype
MGI:2653578
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(NOS3)2Crom/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (145 available)
Tg(NOS3)2Crom mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:80701 )
• decrease in atherosclerosis compared to single Apoe homozygotes
decreased systemic arterial blood pressure ( J:80701 )
• mutants fed a Western diet show a decrease in systemic blood pressure, although heart rate is normal

homeostasis/metabolism
decreased circulating cholesterol level ( J:80701 )
• ~15-16% decrease in plasma cholesterol on a normal chow diet or Western diet compared to single Apoe homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory