Phenotypes Associated with This Genotype

Genotype
MGI:2653551

• Allelic Composition: Tg(Mpz)80.4Wra/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

dysmyelination ( J:78758 )

• mutants exhibit a mixture of hyper- and hypomyelinated fibers

• dysmyelination with about 50% of the large axons ensheathed by single Swann cells that have not formed myelin

decreased nerve conduction velocity ( J:78758 )

• nerve conduction velocity is reduced to 11 m/s

mortality/aging

premature death ( J:78758 )

• median life span is 10 months

behavior/neurological

tremors ( J:78758 )

• mild tremor