Phenotypes Associated with This Genotype

Genotype
MGI:2653496

• Allelic Composition: Runx3^tm1Yito/Runx3^tm1Yito
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:75869 )

• 75% of mice die in the first day after birth

postnatal lethality, complete penetrance ( J:75869 )

• none survive beyond 10 days after birth

digestive/alimentary system

abnormal stomach epithelium morphology ( J:75869 )

• increase in gastric epithelial proliferation and a decrease in gastric epithelial apoptosis in newborns

• gastric epithelial cells are less sensitive to the growth-inhibitory effect of TGF-beta than wild-type cells

• gastric epithelial cells are resistant to the apoptosis-inducing action of TGF-beta

stomach mucosa hyperplasia ( J:75869 )

• hyperplasia of the stomach mucosa due to increased proliferation and suppressed apoptosis in epithelial cells

increased stomach mucosa thickness ( J:75869 )

• stomach mucosa is about twice as thick as in wild-type mice

homeostasis/metabolism

decreased circulating glucose level ( J:75869 )

• blood sugar levels are very low