Phenotypes Associated with This Genotype

Genotype
MGI:2653494

• Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:33159 )

• seen in a mixed background, effects become more severe as the C57BL/6 component to background increased

• most died between 3 and 6 weeks of age

perinatal lethality, incomplete penetrance ( J:79851 )

• seen after extensive backcrossing to C57BL/6 when effects become more severe

• die at or before birth

craniofacial

abnormal occipital bone morphology ( J:79851 )

• seen after extensive backcrossing to C57BL/6 when effects become more severe

• ectopic arches in the occipital bone

abnormal exoccipital bone morphology ( J:33159 )

• seen in a mixed background, effects changed as the C57BL/6 component to background increased

• an extra bone found dorsaorostral to the atlas occasionally became fused to the exoccipital bone

abnormal supraoccipital bone morphology ( J:33159 )

• most caudal part of the supraoccipital bone is lost

growth/size/body

postnatal growth retardation ( J:33159 )

• beginning within the first week

• by the end of 2 weeks, body weight was 1/3 normal

• Background Sensitivity: seen in a mixed background, effects become more severe as the C57BL/6 component to background increased

skeleton

abnormal axial skeleton morphology ( J:33159 )

abnormal occipital bone morphology ( J:79851 )

• seen after extensive backcrossing to C57BL/6 when effects become more severe

• ectopic arches in the occipital bone

abnormal exoccipital bone morphology ( J:33159 )

• seen in a mixed background, effects changed as the C57BL/6 component to background increased

• an extra bone found dorsaorostral to the atlas occasionally became fused to the exoccipital bone

abnormal supraoccipital bone morphology ( J:33159 )

• most caudal part of the supraoccipital bone is lost

abnormal sternocostal joint morphology ( J:33159 )

• rib 6 is the last to attach to the sternum

abnormal rib morphology ( J:79851 , J:33159 )

• C7 ectopic rib becomes less common as C57BL/6 increases in genetic background (J:79851)

rib fusion ( J:33159 )

• cervical rib of C7 fuses to T1

abnormal odontoid process morphology ( J:33159 )

• odontoid attaches to the atlas rather than the axis

vertebral transformation ( J:33159 )

thoracic vertebral transformation ( J:33159 )

• T13 has the characteristics of L1

cervical vertebral transformation ( J:33159 )

• atlas looks much like the axis and axis has the appearance of C3

lumbar vertebral transformation ( J:33159 )

• L6 becomes S1

sacral vertebral transformation ( J:33159 )

• S4 becomes caudal vertebra 1

abnormal sternum ossification ( J:33159 )

• additional ossification at the cranial end of the sternum