Phenotypes Associated with This Genotype

Genotype
MGI:2653476

• Allelic Composition: Sox5^tm1Vlf/Sox5^tm1Vlf; Sox6^tm1Vlf/Sox6^tm1Vlf
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:80666 )

• die approximately at E16.5 from congestive heart failure

cardiovascular system

abnormal blood circulation ( J:80666 )

• accumulation of blood in liver, inferior vena cava and right atrium of the heart

craniofacial

short snout ( J:80666 )

growth/size/body

short snout ( J:80666 )

decreased body length ( J:80666 )

• short trunk

distended abdomen ( J:80666 )

homeostasis/metabolism

edema ( J:80666 )

• generalized edema noted

limbs/digits/tail

short limbs ( J:80666 )

short tail ( J:80666 )

skeleton

abnormal thoracic cage morphology ( J:80666 )

• incomplete thoracic cage

short vertebral column ( J:80666 )

• short vertebral column

abnormal cartilage morphology ( J:80666 )

abnormal chondrocyte morphology ( J:80666 )

• cells develop normally to the prechondrocyte stage, but fail to differentiate into mature chondroblasts

absent cartilage ( J:80666 )

chondrodystrophy ( J:80666 )