Phenotypes Associated with This Genotype

Genotype
MGI:2653474

• Allelic Composition: Sox5^tm1Vlf/Sox5^tm1Vlf
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:80666 )

• mice died at birth due to respiratory distress

craniofacial

abnormal neurocranium morphology ( J:80666 )

• short chondrocranium

cleft secondary palate ( J:80666 )

failure of palatal shelf elevation ( J:80666 )

• at birth, mutant palatal shelves had not elevated and remained vertical

respiratory system

respiratory distress ( J:80666 )

• evident at birth

respiratory failure ( J:80666 )

• failure to breathe

skeleton

abnormal neurocranium morphology ( J:80666 )

• short chondrocranium

abnormal sternum morphology ( J:80666 )

• short, bent inwards and ectopic mineralized intersternebrae

short sternum ( J:80666 )

short ribs ( J:80666 )

• short ribs; results in a bell shaped thoracic cage

abnormal thoracic cage shape ( J:80666 )

• bell shaped thoracic cage

abnormal bone mineralization ( J:80666 )

• mineralization of the vertebral bodies, nasal and presphenoid bones was delayed

digestive/alimentary system

cleft secondary palate ( J:80666 )

failure of palatal shelf elevation ( J:80666 )

• at birth, mutant palatal shelves had not elevated and remained vertical

growth/size/body

cleft secondary palate ( J:80666 )

failure of palatal shelf elevation ( J:80666 )

• at birth, mutant palatal shelves had not elevated and remained vertical

pectus excavatum ( J:80666 )

• sternum is bent inwards