Phenotypes Associated with This Genotype

Genotype
MGI:2653458

• Allelic Composition: Ptdss2^{Gt(KST314)Byg}/Ptdss2^{Gt(KST314)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal testis morphology ( J:80673 )

♂

increased Leydig cell number ( J:80673 )

♂ • in atrophic testes

decreased testis weight ( J:80673 )

♂ • a 13% reduction in testis weight for about 90% of male mice

testicular atrophy ( J:80673 )

♂ • testes about 30% of normal size in 3 out of 25 male

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:80673 )

• increased levels in males possibly due to subtle Sertioli cell dysfunction

reproductive system

abnormal testis morphology ( J:80673 )

♂

increased Leydig cell number ( J:80673 )

♂ • in atrophic testes

decreased testis weight ( J:80673 )

♂ • a 13% reduction in testis weight for about 90% of male mice

testicular atrophy ( J:80673 )

♂ • testes about 30% of normal size in 3 out of 25 male

male infertility ( J:80673 )

♂ • although all females and most males were fertile, about 10% of males were infertile or subfertile