Phenotypes Associated with This Genotype

Genotype
MGI:2653198

• Allelic Composition: Zic1^tm1Jaru/Zic1^tm1Jaru
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:73794 )

• 50% of mice died within 1 day of birth

postnatal lethality, complete penetrance ( J:73794 )

• remaining 50% of mice died within 3 weeks of birth

behavior/neurological

abnormal suckling behavior ( J:73794 )

• less milk in stomach than littermate controls, authors suggest as a result of poor suckling

• authors attribute growth retardation to less milk ingestion

impaired righting response ( J:73794 )

• extended period of time required to right self; sometimes completely unable to do so

ataxia ( J:73794 )

• often lied on backs, forelimbs extended anteriorly and making irregular motions

impaired limb coordination ( J:73794 )

• loss of coordinated movement of all 4 limbs

abnormal gait ( J:73794 )

• dragged hindlimbs

• unable to walk a straight line

• most fell to one side

growth/size/body

postnatal growth retardation ( J:73794 )

• significantly smaller than littermate controls at P2, authors suggest due to poor suckling which resulted in decreased amounts of milk in stomach

skeleton

kyphosis ( J:73794 )

• in thoracic region

nervous system

abnormal cerebellum development ( J:73794 )

• evident at E17.5

abnormal cerebellar foliation ( J:73794 )

• folia in anterior lobe completely missing in almost all cases

• not restricted to anterior lobe, however, as all fissures appeared shallow

cerebellum hypoplasia ( J:73794 )

• layer organization normal, however

• differentiation and neural circuit formation fundamentally normal