Phenotypes for Tlr3 MGI:2653141 MGI Mouse

immune system phenotype ( J:72167 )

N	• normal lymphocyte development • normal expression of CD3, B220, CD4, and CD8 in thymocytes and splenocytes

abnormal B cell physiology ( J:72167 )

• impaired expression of CD69, CD80, and CD86 in response to poly(I:C), but not LPS

• impaired expression of CD69 in response to viral genomic dsRNA from Type I Lang mammalian reovirus

abnormal macrophage physiology ( J:72167 )

• impaired ability to produce IL6, IL12 and TNF-alpha in response to poly(I:C), a synthetic dsRNA analogue

• production of IL6, IL12, and TNF-alpha in response to LPS, PGN, LTA, zymosan, mannan, or CpG DNA was comparable to wild-type controls

decreased inflammatory response ( J:72167 )

• resistant to poly(I:C)-induced shock compared to wild-type mice

• produced less IL12 after poly(I:C) i.p. injection

• retain memory of platform location in Morris maze tests up to 120 hours compared to 72 hours in controls

abnormal spatial working memory ( J:163748 )

• enhanced working memory

abnormal emotion/affect behavior ( J:163748 )

• in open field tests and elevated + mazes

abnormal fear-related response ( J:163748 )

decreased fear-related response ( J:163748 )

• less cued fear response to a tone

increased fear-related response ( J:163748 )

• greater hippocampus dependent contextual fear response, freezing times

abnormal response to novel object ( J:163748 )

• increased interest in novel objects

impaired coordination ( J:163748 )

• poorer rotarod performance and motor learning

abnormal hippocampus development ( J:163748 )

• increased hippocampal neurogenesis

• increased in volume

abnormal dentate gyrus morphology ( J:163748 )