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Phenotypes Associated with This Genotype
Genotype
MGI:2653131
Allelic
Composition
Krt14tm2Der/Krt14+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14tm2Der mutation (0 available); any Krt14 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Blistering on the left front leg and abdomen of Krt14tm2Der/Krt14+ pups

mortality/aging
• mutants die a week after birth due to severe blistering

integument
• basal keratinocytes contain keratin clumps and short keratin filaments, in contrast to wild type keratinocytes which contain long keratin filaments
• however, normal keratin filaments are seen in the suprabasal layer of the epidermis
• pups develop large blisters on their forelimbs and trunk
• lymphocyte infiltration is seen in blistering areas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epidermolysis bullosa simplex Dowling-Meara type DOID:0060735 OMIM:131760
J:67320


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory