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Phenotypes Associated with This Genotype
Genotype
MGI:2653129
Allelic
Composition
Krt14tm1Der/Krt14tm1Der
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14tm1Der mutation (0 available); any Krt14 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Severe blisters on the front legs, paws, and chest of Krt14tm1Der/Krt14tm1Der pups

mortality/aging
• usually die within 48 hours after birth

integument
• basal keratinocytes of lesional areas contain keratin clumps
• isolated primary keratinocytes subjected to heat shock show a collapsed perinuclear intermediate filament network and cytoplasmic keratin aggregates
• mutants develop extensive blisters on the front legs, paws, and chest within hours after birth
• the separation occurs within the basal cell layer of the epidermis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epidermolysis bullosa simplex DOID:4644 OMIM:601001
OMIM:615425
J:67320


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory