Phenotypes Associated with This Genotype

Genotype
MGI:2653115

• Allelic Composition: Fga^tm1Jld/Fga^tm1Jld; Thbd^tm2Rdr/Thbd^tm2Rdr
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:82224 )

• unlike Thbd^tm2Rdr homozygotes which are completely resorbed by E9.5, double homozygotes are recovered as late as E10.5

embryo

embryonic growth arrest ( J:82224 )

• double homozygotes exhibit embryonic growth arrest at E8.5

• inhibition of fibrinolysis with tranexamic acid has the same effect as complete elimination of fibrinogen and results in recovery of growth-arrested embryos at E9.5

small ectoplacental cone ( J:82224 )

• double homozygotes display a proliferation defect in trophoblast cells of the ectoplacental cone

• similarly, inhibition of fibrinolysis with tranexamic acid fails to augment proliferation of ectoplacental trophoblast cells

• in contrast, both the absence of fibrinogen and inhibition of fibrinolysis prevents DNA fragmentation in trophoblast giant cells, as detected by TUNEL assay