Phenotypes Associated with This Genotype

Genotype
MGI:2653095

• Allelic Composition: Abcc1^tm1Acs/Abcc1^tm1Acs
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:44305 )

• homozygotes exhibit a 25-90% increase in glutathione (GSH) levels in most tissues, including breast, heart, lung, kidney, muscle, colon, testes, ovary, bone marrow cells, blood mononuclear leukocytes, and blood erythrocytes, but NOT in liver or small intestine

• notably, no increase in the activity of gamma-glutamylcysteine synthetase, the rate-limiting enzyme for GSH synthesis, is observed in any of the tissues analyzed

increased physiological sensitivity to xenobiotic ( J:44305 )

• homozygotes exhibit a 2-fold increase in sensitivity to etoposide phosphate, associated with higher bone marrow toxicity relative to wild-type mice

• in contrast, no significant differences in acute sodium arsenite toxicity or acute cisplatin toxicity are observed

hematopoietic system

hematopoietic system phenotype ( J:44305 )

N • homozygotes are viable at least up to 4 months and display normal fertility, growth, behavior, and tissue/organ morphology, with no significant differences in hematological parameters relative to wild-type mice