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Phenotypes Associated with This Genotype
Genotype
MGI:2652553
Allelic
Composition
Plcb1tm1Hssh/Plcb1tm1Hssh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb1tm1Hssh mutation (0 available); any Plcb1 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice died at the age of 3 weeks (J:43077)
• most mice died at the age of 3 weeks (J:43077)

behavior/neurological
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid) (J:43077)
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid) (J:43077)
• exhibited prior to 3 wks of age (J:43077)
• tonic-clonic or tonic extension of the whole body (J:43077)
• putatively evoked by hippocampal hyperexcitability (J:43077)
• exhibited prior to 3 wks of age (J:43077)
• tonic-clonic or tonic extension of the whole body (J:43077)
• putatively evoked by hippocampal hyperexcitability (J:43077)

growth/size/body

nervous system
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid) (J:43077)
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid) (J:43077)
• exhibited prior to 3 wks of age (J:43077)
• tonic-clonic or tonic extension of the whole body (J:43077)
• putatively evoked by hippocampal hyperexcitability (J:43077)
• exhibited prior to 3 wks of age (J:43077)
• tonic-clonic or tonic extension of the whole body (J:43077)
• putatively evoked by hippocampal hyperexcitability (J:43077)
• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures (J:43077)
• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures (J:43077)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:43077


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory