Mouse Genome Informatics
hm
    Plcb1tm1Hssh/Plcb1tm1Hssh
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most mice died at the age of 3 weeks

behavior/neurological
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability

growth/size/body

nervous system
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability
• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:43077