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Phenotypes Associated with This Genotype
Genotype
MGI:2652461
Allelic
Composition		 Tg(THY1-APP)2Somm/0
Genetic
Background		 involves: C57BL/6J * DBA/2
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:44603 )
• develop amyloid beta deposits (plaques) in the neocortex and hippocampus by 18 months of age
• majority of deposits are of the diffuse type with a few congophilic plaques
brain inflammation ( J:44603 )
• mutants exhibit inflammatory responses in the brain, showing a glial response

immune system
brain inflammation ( J:44603 )
• mutants exhibit inflammatory responses in the brain, showing a glial response

homeostasis/metabolism
amyloid beta deposits ( J:44603 )
• develop amyloid beta deposits (plaques) in the neocortex and hippocampus by 18 months of age
• majority of deposits are of the diffuse type with a few congophilic plaques

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory