Mouse Genome Informatics
tg
    Tg(Thy1-APP)3Somm/0
involves: C57BL/6J * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• mice exhibit aneurysm-like vasodilation unlike in wild-type mice
• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice
• mice exhibit leakage in the blood-brain barrier unlike wild-type mice
• mutants exhibit inflammatory responses in the brain, showing a massive glial response
• loss of pyramidal neurons in the vicinity of amyloid beta deposits in the CA3 area
• in the neocortex, hippocampus, and thalamus and to a lesser degree in other regions such as septum, striatum, brainstem, and white matter (J:67583)
• local distortion of the cholinergic fiber network is seen in the vicinity of plaques
• local loss of neurons in the vicinity of plaques
• at 24 months
• develop amyloid beta deposits in the neocortex and hippocampus starting at 6 months of age, which increase in size and number with age (J:44603)
• by 24 months of age, deposits occupy a substantial area of the neocortex and hippocampus and are found in the thalamus and olfactory nucleus and are isolated in the caudate putamen (J:44603)
• develop almost exclusively congophilic plaques already at their first appearance (J:44603)
• at 24 months (J:134832)

other phenotype
• in the neocortex, hippocampus, and thalamus and to a lesser degree in other regions such as septum, striatum, brainstem, and white matter (J:67583)
• develop amyloid beta deposits in the neocortex and hippocampus starting at 6 months of age, which increase in size and number with age (J:44603)
• by 24 months of age, deposits occupy a substantial area of the neocortex and hippocampus and are found in the thalamus and olfactory nucleus and are isolated in the caudate putamen (J:44603)
• develop almost exclusively congophilic plaques already at their first appearance (J:44603)
• at 24 months (J:134832)

immune system
• mice exhibit cerebral amyloid angiopathy associated vasculitis unlike wild-type mice
• mutants exhibit inflammatory responses in the brain, showing a massive glial response

cardiovascular system
• mice exhibit aneurysm-like vasodilation unlike in wild-type mice
• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice
• bicuculline-treated mice exhibit delayed and reduced amplitude of changes in cerebral blood volume compared with similarly treated wild-type mice
• at 25 months, acetazolamide-treated mice exhibit a smaller increase in the percent change of cerebral blood volume compared with similarly treated wild-type mice
• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice
• mice exhibit leakage in the blood-brain barrier unlike wild-type mice
• mice exhibit cerebral amyloid angiopathy associated vasculitis unlike wild-type mice

muscle
• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice

homeostasis/metabolism
• bicuculline-treated mice exhibit delayed and reduced amplitude of changes in cerebral blood volume compared with similarly treated wild-type mice
• at 25 months, acetazolamide-treated mice exhibit a smaller increase in the percent change of cerebral blood volume compared with similarly treated wild-type mice
• during posthypoxic recovery, the spike amplitude in hippocampal region CA1 after stimulation of Schaffer collaterals in region CA3 is less than in similarly treated wild-type mice
• at 4 months, hypoxic tolerance is impaired compared to in similarly treated wild-type mice

behavior/neurological
• at 6 months, mice exhibit reduced exploratory learning compared with wild-type mice
• object recognition is impaired compared to in wild-type mice

hematopoietic system

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:44603
Cerebral Amyloid Angiopathy, App-Related 605714 J:67583