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Phenotypes Associated with This Genotype
Genotype
MGI:2652424
Allelic
Composition
Galctm1Wngr/Galctm1Wngr
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galctm1Wngr mutation (0 available); any Galc mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death occurs at around the two months of age

behavior/neurological
• age of onset 25-30 days of age
• age of onset 25-30 days of age

growth/size/body
• mice gain weight until around 35-40 days of age, maintain their weight for a few days, and then begin to lose weight and die 10-15 days later

homeostasis/metabolism
• low galactocerebrosidase activity measure in brain, liver, spleen, heart, and kidney

immune system
• macrophage infiltration was noted in cerebellar white matter, brainstem, cerebral white matter, cerebral gray matter and peripheral nerve of a 49 day old mouse. infiltration was not as extensive as compared to a 36 day old twitcher mouse

nervous system
• observed in cerebellar white matter, brainstem, cerebral white matter and cerebral gray matter
• observed in peripheral nerve of 49 day old mouse; described as moderate in comparison to a 36 day old twitcher mouse

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Krabbe disease DOID:10587 OMIM:245200
J:78691


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory