Phenotypes Associated with This Genotype

Genotype
MGI:2652407

• Allelic Composition: Tg(CD2-Nfat5)1Snh/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased splenocyte proliferation ( J:80066 )

• splenocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress

• 70% reduction of splenocytes in S phase

thymus hypoplasia ( J:80066 )

• 30% reduction in thymus cellularity

abnormal T cell differentiation ( J:80066 )

decreased T cell number ( J:80066 )

• reduction in numbers of peripheral T cells

decreased CD4-positive, alpha-beta T cell number ( J:80066 )

• 25% reduction in percentage of CD4+ cells in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:80066 )

• 50% reduction in percentage of CD8+ cells in the spleen

• reduction in percentage of CD8+ cells in peripheral lymph nodes

spleen hypoplasia ( J:80066 )

• 15% reduction in spleen cellularity

abnormal T cell physiology ( J:80066 )

• mutants develop impaired antigen-specific antibody and cytotoxic T cell responses

decreased T cell proliferation ( J:80066 )

• thymocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress

• T cells exhibit impaired growth under conditions of medium depletion compared to control T cells, however they do not show increased sensitivity to a reduction in pH or serum deprivation, suggesting that sensitivity is due to osmolarity

• T cells exhibit impaired growth in response to amino acid deprivation

abnormal cytotoxic T cell physiology ( J:80066 )

• mutants develop impaired cytotoxic T cell responses

hematopoietic system

decreased splenocyte proliferation ( J:80066 )

• splenocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress

• 70% reduction of splenocytes in S phase

thymus hypoplasia ( J:80066 )

• 30% reduction in thymus cellularity

abnormal T cell differentiation ( J:80066 )

decreased T cell number ( J:80066 )

• reduction in numbers of peripheral T cells

decreased CD4-positive, alpha-beta T cell number ( J:80066 )

• 25% reduction in percentage of CD4+ cells in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:80066 )

• 50% reduction in percentage of CD8+ cells in the spleen

• reduction in percentage of CD8+ cells in peripheral lymph nodes

spleen hypoplasia ( J:80066 )

• 15% reduction in spleen cellularity

abnormal T cell physiology ( J:80066 )

• mutants develop impaired antigen-specific antibody and cytotoxic T cell responses

decreased T cell proliferation ( J:80066 )

• thymocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress

• T cells exhibit impaired growth under conditions of medium depletion compared to control T cells, however they do not show increased sensitivity to a reduction in pH or serum deprivation, suggesting that sensitivity is due to osmolarity

• T cells exhibit impaired growth in response to amino acid deprivation

abnormal cytotoxic T cell physiology ( J:80066 )

• mutants develop impaired cytotoxic T cell responses

cellular

decreased T cell proliferation ( J:80066 )

• thymocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress

• T cells exhibit impaired growth under conditions of medium depletion compared to control T cells, however they do not show increased sensitivity to a reduction in pH or serum deprivation, suggesting that sensitivity is due to osmolarity

• T cells exhibit impaired growth in response to amino acid deprivation

decreased splenocyte proliferation ( J:80066 )

• splenocyte cultures show increased sensitivity (impaired cell growth) to hypertonic stress

• 70% reduction of splenocytes in S phase

endocrine/exocrine glands

thymus hypoplasia ( J:80066 )

• 30% reduction in thymus cellularity