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Phenotypes Associated with This Genotype
Genotype
MGI:2652383
Allelic
Composition		 Psen1tm1Dgf/Psen1+
Tg(APPSWE)2576Kha/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (57 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
gliosis ( J:66147 )
• mutants exhibit enhanced reactive gliosis compared to single Tg(APPSWE)2576Kha mice
amyloid beta deposits ( J:66147 )
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice

homeostasis/metabolism
amyloid beta deposits ( J:66147 )
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice

cellular
gliosis ( J:66147 )
• mutants exhibit enhanced reactive gliosis compared to single Tg(APPSWE)2576Kha mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory