Phenotypes Associated with This Genotype

Genotype
MGI:2652380

• Allelic Composition: Tg(SFTPC-MST1R)71Mhw/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenoma incidence ( J:79080 )

• multiple lung tumors mostly located in peripheral regions of the lungs

• mostly solid alveolar adenomas showing early progression towards adenocarcinoma

• tumors typically initiate at 2 months of age and it takes 6-10 months for tumors to progress from a single mass to multiple nodules

increased lung adenocarcinoma incidence ( J:79080 )

• transition from early adenomas to later adenocarcinomas

respiratory system

increased lung adenoma incidence ( J:79080 )

• multiple lung tumors mostly located in peripheral regions of the lungs

• mostly solid alveolar adenomas showing early progression towards adenocarcinoma

• tumors typically initiate at 2 months of age and it takes 6-10 months for tumors to progress from a single mass to multiple nodules

increased lung adenocarcinoma incidence ( J:79080 )

• transition from early adenomas to later adenocarcinomas

respiratory distress ( J:79080 )

• between 6 and 14 months of age, animals show signs of respiratory distress