Analysis Tools
immune system
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• mature T cells fail to proliferate upon T cell receptor activation (by anti-CD3e or concanavalin A); proliferation defects are observed in both CD4+ and CD8+ populations
• proliferation defects are only partially overcome by exogenous Il-2
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• animals have reduced numbers of mature T cells, particularly CD4+ T cells, resulting in a decreased CD4:CD8 ratio
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• numbers of CD4+ and CD8+ T cells are increased relative to Itk-null mice; however total T cell numbers are normal
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• mice infected with Toxoplasma gondii survive the early infection which requires natural killer cells, but by 30 days post-infection, mice are visibly ill and have a mean survival time of 41 days
• after 30 days, mice have increased numbers of brain cysts indicating defect in ability to limit infection
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hematopoietic system
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• mature T cells fail to proliferate upon T cell receptor activation (by anti-CD3e or concanavalin A); proliferation defects are observed in both CD4+ and CD8+ populations
• proliferation defects are only partially overcome by exogenous Il-2
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• animals have reduced numbers of mature T cells, particularly CD4+ T cells, resulting in a decreased CD4:CD8 ratio
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• numbers of CD4+ and CD8+ T cells are increased relative to Itk-null mice; however total T cell numbers are normal
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cellular
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• mature T cells fail to proliferate upon T cell receptor activation (by anti-CD3e or concanavalin A); proliferation defects are observed in both CD4+ and CD8+ populations
• proliferation defects are only partially overcome by exogenous Il-2
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