Analysis Tools
cardiovascular system
|
• unlike hypertensive homozygous null mice, conscious conditional mutants exhibit normal chronic arterial BPs under resting conditions, despite abolition of vasorelaxing responses to ANP
• however, infusion of ANP at a dose of 500 ng/kg BW fails to lower arterial BP in conscious conditional mutants but significantly reduces systolic and diastolic BP in wild-type and homozygous Npr1tm1Kuhn mice
• notably, acute vascular volume expansion results in a rapid, significant increase in systolic BP and slight increase in diastolic BP during the 15 min of high-volume infusion; such changes are fully reversible 10 min after volume overload and are absent in homozygous Npr1tm1Kuhn mice
|
|
• vasorelaxing responses to atrial natriuretic peptide (ANP) are abolished in isolated preconstricted arteries from conditional mutant mice
• small relaxation in response to high ANP concentrations, also observed in phenylephrine (PE)-contracted arteries in the absence of ANP, indicating a spontaneous (ANP-independent) loss of tone
|
muscle
|
• vasorelaxing responses to atrial natriuretic peptide (ANP) are abolished in isolated preconstricted arteries from conditional mutant mice
• small relaxation in response to high ANP concentrations, also observed in phenylephrine (PE)-contracted arteries in the absence of ANP, indicating a spontaneous (ANP-independent) loss of tone
|
