Phenotypes Associated with This Genotype

Genotype
MGI:2652119

• Allelic Composition: Tg(Camk2a-Fyn-531)1Nko/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:59490 )

• sudden death after weaning; survival rate shows correlation with level of transgene expression

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:59490 )

• reduced penthylenetetrazole dosage required for tonic extension

• reduced lethal penthylenetetrazole dosage

abnormal motor capabilities/coordination/movement ( J:59490 )

• lines expressing high levels of the transgene show spontaneous running and bouncing fits

abnormal seizure response to electrical stimulation ( J:59490 )

• increased seizure activity in response to once-daily electrical stimution of the amygdala

• prolonged after discharge (greater than 30 seconds) is often observed

abnormal kindling response ( J:59490 )

• exhibit accelerated kindling in response to once-daily stimulation of the amygdala

• kindling is repressed by MK-108 administration

tonic seizures ( J:59490 )

• tonic convulsion; seizure severity shows correlation with level of transgene expression

nervous system

increased susceptibility to pharmacologically induced seizures ( J:59490 )

• reduced penthylenetetrazole dosage required for tonic extension

• reduced lethal penthylenetetrazole dosage

abnormal seizure response to electrical stimulation ( J:59490 )

• increased seizure activity in response to once-daily electrical stimution of the amygdala

• prolonged after discharge (greater than 30 seconds) is often observed

abnormal kindling response ( J:59490 )

• exhibit accelerated kindling in response to once-daily stimulation of the amygdala

• kindling is repressed by MK-108 administration

tonic seizures ( J:59490 )

• tonic convulsion; seizure severity shows correlation with level of transgene expression