Phenotypes Associated with This Genotype

Genotype
MGI:2652091

• Allelic Composition: Dsp^tm2Efu/Dsp^tm2Efu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:51903 )

• by E6.5; followed by reduction in adherens junctions and morphological signs of cellular degeneration

embryo

abnormal ectoderm development ( J:51903 )

• defects in cell-cell adhesion results in partial delamination of the endodermal layer; disruptions are also seen in the ectodermal layer

abnormal endoderm development ( J:51903 )

• defects in cell-cell adhesion results in partial delamination of the endodermal layer; disruptions are also seen in the ectodermal layer

decreased embryo size ( J:51903 )

• mutant embryos are smaller than littermates

abnormal embryonic tissue morphology ( J:51903 )

• absence of desmosome

abnormal egg cylinder morphology ( J:51903 )

• defects in egg cylinder elongation

growth/size/body

decreased embryo size ( J:51903 )

• mutant embryos are smaller than littermates