cellular
|
|
• the ovaries of superovulated females occasionally have enlarged denuded oocytes lacking surrounding cumulus cells indicating that follicular recruitment occurs but some oocytes are trapped within follicles and not released
|
|
|
• reduction of oocytes that can develop to embryos
|
|
|
• occasionally, ovaries show an increase in the number of zona pellucida remnants
|
reproductive system
|
|
• the ovaries of superovulated females occasionally have enlarged denuded oocytes lacking surrounding cumulus cells indicating that follicular recruitment occurs but some oocytes are trapped within follicles and not released
|
|
|
• reduction of oocytes that can develop to embryos
|
|
|
• occasionally, ovaries show an increase in the number of zona pellucida remnants
|
|
|
• reduction in numbers of follicles in occasional ovaries at various stages
|
ovary cyst
(
J:69611
)
|
|
• rare incidence of uni- and bilateral cysts at 1 yr of age
|
|
|
• superovulated females ovulate ~66% the number of oocytes as controls
|
|
|
• Background Sensitivity: females are subfertile, however the reduced fertility is less severe on the mixed 129S7/SvEvBrd and C57BL/6J background than on the 129S7/SvEvBrd background
|
|
|
• average litter size is 4.93 (+/- 0.25)
|
endocrine/exocrine glands
|
|
• reduction in numbers of follicles in occasional ovaries at various stages
|
ovary cyst
(
J:69611
)
|
|
• rare incidence of uni- and bilateral cysts at 1 yr of age
|
growth/size/body
ovary cyst
(
J:69611
)
|
|
• rare incidence of uni- and bilateral cysts at 1 yr of age
|


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