skeleton
• phenotype is quantitatively similar, but less pronounced in males compared to females
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• calvarial cortical thickness is reduced to ~80% of control
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• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
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• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
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• trabecular separation is increased by 44% compared to controls
• in secondary spongiosa of distal femur in 6-week old females, trabecular separation is increased; trabecular connectivity is 35% lower than normal
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• trabecular bone volume is decreased by 46%
• in secondary spongiosa of distal femur in 6-week old females, cancellous bone volume is ~24% lower than controls
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• trabecular number is decreased by 29%
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• trabecular thickness is decreased by 25%
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• phenotype is quantitatively similar, but less pronounced in males compared to females
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• increase in osteoclast erosion surface accompanies increase in osteoid
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• amount of osteoid is significantly increased in female mutants at 6-weeks
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• mineral apposition rate is impaired in 6-week old females
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• in 3-week old females, epiphyseal bone formation rate is reduced to ~42% of control mice
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craniofacial
• calvarial cortical thickness is reduced to ~80% of control
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immune system
• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
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• amount of osteoid is significantly increased in female mutants at 6-weeks
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hematopoietic system
• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
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• amount of osteoid is significantly increased in female mutants at 6-weeks
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cellular
• increase in osteoclast erosion surface accompanies increase in osteoid
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