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Phenotypes Associated with This Genotype
Genotype
MGI:2651814
Allelic
Composition
Igf1rtm2Arge/Igf1rtm2Arge
Tg(BGLAP-cre)1Clem/0
Genetic
Background
involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm2Arge mutation (1 available); any Igf1r mutation (85 available)
Tg(BGLAP-cre)1Clem mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• phenotype is quantitatively similar, but less pronounced in males compared to females
• calvarial cortical thickness is reduced to ~80% of control
• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
• trabecular separation is increased by 44% compared to controls
• in secondary spongiosa of distal femur in 6-week old females, trabecular separation is increased; trabecular connectivity is 35% lower than normal
• trabecular bone volume is decreased by 46%
• in secondary spongiosa of distal femur in 6-week old females, cancellous bone volume is ~24% lower than controls
• trabecular number is decreased by 29%
• trabecular thickness is decreased by 25%
• phenotype is quantitatively similar, but less pronounced in males compared to females
• increase in osteoclast erosion surface accompanies increase in osteoid
• amount of osteoid is significantly increased in female mutants at 6-weeks
• mineral apposition rate is impaired in 6-week old females
• in 3-week old females, epiphyseal bone formation rate is reduced to ~42% of control mice

craniofacial
• calvarial cortical thickness is reduced to ~80% of control

immune system
• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
• amount of osteoid is significantly increased in female mutants at 6-weeks

hematopoietic system
• significant reduction in number (67-69%) per bone perimeter is seen relative to controls
• amount of osteoid is significantly increased in female mutants at 6-weeks

cellular
• increase in osteoclast erosion surface accompanies increase in osteoid


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory