Phenotypes Associated with This Genotype

Genotype
MGI:2651800

• Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:71775 )

• embryos fail to develop past E11.5

nervous system

abnormal oligodendrocyte morphology ( J:71775 )

• oligodendrocyte development is arrested at the proligodendroblast stage in spinal cord explants from E9.5 embryos, with a greater than 10-fold reduction in the number of galactosylcerebroside-positive oligodendroctyes

• of the oligodendrocytes that do differentiate, all fail to ensheath neurites

cellular

abnormal oligodendrocyte morphology ( J:71775 )

• oligodendrocyte development is arrested at the proligodendroblast stage in spinal cord explants from E9.5 embryos, with a greater than 10-fold reduction in the number of galactosylcerebroside-positive oligodendroctyes

• of the oligodendrocytes that do differentiate, all fail to ensheath neurites