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Phenotypes Associated with This Genotype
Genotype
MGI:2651673
Allelic
Composition
Btktm1Wk/Btktm1Wk
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Wk mutation (1 available); any Btk mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• partial arrest of B cell development
• increased numbers of pro-B cells
• decreased numbers of mature B cells (J:28968)
• numbers of mature recirculating B cells (B220highIgM+, HSAlowIgM+, and B220+IgD+) are reduced (J:82298)
• germinal centers are infrequent in TNP-LPS immunized mutants
• germinal centers are smaller in TNP-LPS immunized mutants
• defective B cell activation after immunization with T-independent type II antigens
• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type
• decreased serum IgG3 concentration (J:28968)
(J:82298)
• decreased serum IgM concentration (J:28968)
(J:82298)

immune system
• partial arrest of B cell development
• increased numbers of pro-B cells
• decreased numbers of mature B cells (J:28968)
• numbers of mature recirculating B cells (B220highIgM+, HSAlowIgM+, and B220+IgD+) are reduced (J:82298)
• germinal centers are infrequent in TNP-LPS immunized mutants
• germinal centers are smaller in TNP-LPS immunized mutants
• defective B cell activation after immunization with T-independent type II antigens
• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type
• decreased serum IgG3 concentration (J:28968)
(J:82298)
• decreased serum IgM concentration (J:28968)
(J:82298)
• smaller and fewer germinal centers are observed in response to TI-I antigen, TNP-LPS

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:28968


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory