Mouse Genome Informatics
hm
    Btktm1Wk/Btktm1Wk
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• decreased numbers of mature B cells (J:28968)
• numbers of mature recirculating B cells (B220highIgM+, HSAlowIgM+, and B220+IgD+) are reduced (J:82298)
• partial arrest of B cell development (J:28968)
• defective B cell activation after immunization with T-independent type II antigens (J:28968)
• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)
• increased numbers of pro-B cells (J:28968)
• germinal centers are infrequent in TNP-LPS immunized mutants (J:82298)
• germinal centers are smaller in TNP-LPS immunized mutants (J:82298)
• decreased serum IgG3 concentration (J:28968)
(J:82298)
• decreased serum IgM concentration (J:28968)
(J:82298)

immune system
• decreased numbers of mature B cells (J:28968)
• numbers of mature recirculating B cells (B220highIgM+, HSAlowIgM+, and B220+IgD+) are reduced (J:82298)
• partial arrest of B cell development (J:28968)
• defective B cell activation after immunization with T-independent type II antigens (J:28968)
• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)
• increased numbers of pro-B cells (J:28968)
• germinal centers are infrequent in TNP-LPS immunized mutants (J:82298)
• germinal centers are smaller in TNP-LPS immunized mutants (J:82298)
• decreased serum IgG3 concentration (J:28968)
(J:82298)
• decreased serum IgM concentration (J:28968)
(J:82298)
• smaller and fewer germinal centers are observed in response to TI-I antigen, TNP-LPS (J:82298)

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:28968