Phenotypes Associated with This Genotype

Genotype
MGI:2651597

• Allelic Composition: Tnfsf4^tm1Sug/Tnfsf4^tm1Sug
• Genetic Background: B6.129S4-Tnfsf4^tm1Sug

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:80214 )

• reduced hapten-specific T cell proliferative response

decreased susceptibility to type IV hypersensitivity reaction ( J:80214 )

• decreased ear swelling 24 hours following challenge with 4-dinitrofluorobenzene (DNFB), 6-trinitrochlorobenzene (TNCB), and FITC compared to wild-type

abnormal cytokine secretion ( J:80214 )

• reduced hapten-specific T cell proliferative response; however, migratory responses are normal

hematopoietic system

decreased T cell proliferation ( J:80214 )

• reduced hapten-specific T cell proliferative response

cellular

decreased T cell proliferation ( J:80214 )

• reduced hapten-specific T cell proliferative response