Phenotypes Associated with This Genotype

Genotype
MGI:2651491

• Allelic Composition: Ugcg^tm1Rlp/Ugcg^tm1Rlp
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:76736 , J:80111 )

• gastrulating homozygous mutant embryos start undergoing resorption at ~E7.5 (J:76736)

• only small remnants of embryonic tissue are detected at E8.5 (J:76736)

• all mutant embryos are completely resorbed by E9.5 (J:76736)

embryo

increased ectoderm apoptosis ( J:76736 , J:80111 )

• at E7.5, homozygotes display increased ectoderm apoptosis relative to wild-type embryos (J:76736)

• however, increased apoptosis is also noted in other regions of the mutant embryos (J:76736)

decreased embryo size ( J:76736 , J:80111 )

• at E7.5, homozygous mutant embryos are smaller than wild-type embryos (J:76736)

abnormal extraembryonic tissue morphology ( J:76736 , J:80111 )

• at E7.5, homozygotes exhibit a smaller extraembryonic portion relative to the embryonic portion (J:76736)

abnormal Reichert's membrane morphology ( J:76736 )

• at E7.5, the Reichert's membrane is abnormally adhered to the decidua

disorganized extraembryonic tissue ( J:76736 )

• at E7.5, all three major cavities - exocoelom, amniotic, and ectoplacental - are present but appear disorganized and significantly smaller in size

growth/size/body

decreased embryo size ( J:76736 , J:80111 )

• at E7.5, homozygous mutant embryos are smaller than wild-type embryos (J:76736)

cellular

increased ectoderm apoptosis ( J:76736 , J:80111 )

• at E7.5, homozygotes display increased ectoderm apoptosis relative to wild-type embryos (J:76736)

• however, increased apoptosis is also noted in other regions of the mutant embryos (J:76736)