Phenotypes Associated with This Genotype

Genotype
MGI:2451332

• Allelic Composition: Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased embryo size ( J:79882 )

• beginning at E14.5, mice carrying a paternally-inherited allele are smaller than wild-type mice

decreased body weight ( J:79882 )

• mice carrying a paternally-inherited allele weigh 20%-25% less than wild-type littermates up to 6 weeks of age

• weight so internal organs (kidney, liver and lung) are decreased proportional to weight reduction

embryo

decreased embryo size ( J:79882 )

• beginning at E14.5, mice carrying a paternally-inherited allele are smaller than wild-type mice

liver/biliary system

decreased liver weight ( J:79882 )

• in mice carrying a paternally-inherited allele

renal/urinary system

decreased kidney weight ( J:79882 )

• in mice carrying a paternally-inherited allele

respiratory system

decreased lung weight ( J:79882 )

• in mice carrying a paternally-inherited allele

cellular

maternal imprinting ( J:79882 )

• mice do not exhibit defects when the allele is inherited maternally