Phenotypes Associated with This Genotype

Genotype
MGI:2451312

• Allelic Composition: Pax3^Sp-2H/Pax3^Sp-2H
• Genetic Background: involves: DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

open neural tube ( J:60939 )

• 86% of embryos fail to close their neural tubes in culture

spina bifida ( J:60939 )

• frequency of spina bifida (82-88%) is similar on the NZW, DBA/2 or stock strain background

exencephaly ( J:60939 )

• Background Sensitivity: mutants backcrossed for 4 generations onto a DBA/2 background exhibit a reduced frequency (35.7%) of cranial neural tube defects compared to mutants on a NZW background (74.3%) or a stock strain (75%)

embryo

open neural tube ( J:60939 )

• 86% of embryos fail to close their neural tubes in culture

spina bifida ( J:60939 )

• frequency of spina bifida (82-88%) is similar on the NZW, DBA/2 or stock strain background