Phenotypes Associated with This Genotype

Genotype
MGI:2451250

• Allelic Composition: Cacnb2^tm1Rgg/Cacnb2^tm1Rgg; Pde6b^rd1/Pde6b^rd1; Tg(Myh6-Cacnb2)1Rgg/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina photoreceptor cell number ( J:79923 )

• progressive loss of photoreceptor cell bodies

• increased apoptotic cell death at 21 days of age

retina photoreceptor degeneration ( J:79923 )

• degeneration of photoreceptors occurs but is delayed at P16, P18, and P21 compared to homozygous Pde6b mutants

thin retina outer nuclear layer ( J:79923 )

• progressive thinning of the outer nuclear layer

disorganized retina outer plexiform layer ( J:80080 )

• the OPL appears disorganized

thin retina outer plexiform layer ( J:80080 )

• the OPL appears thinner than wild-type and other controls

abnormal eye physiology ( J:80080 )

• mutant mice show decreased sensitivity to light

abnormal eye electrophysiology ( J:80080 )

• the b-wave of mutant mice is reduced in amplitude at all flash intensities; the a-wave appears similar to controls

abnormal cone electrophysiology ( J:80080 )

• cone ERGs of mutant mice are smaller in amplitude and negative in polarity

nervous system

decreased retina photoreceptor cell number ( J:79923 )

• progressive loss of photoreceptor cell bodies

• increased apoptotic cell death at 21 days of age

retina photoreceptor degeneration ( J:79923 )

• degeneration of photoreceptors occurs but is delayed at P16, P18, and P21 compared to homozygous Pde6b mutants