Phenotypes Associated with This Genotype

Genotype
MGI:2451225

• Allelic Composition: Numb^tm1Ynj/Numb^tm1Ynj; Numbl^tm1Wmz/Numbl^tm1Wmz; Tg(Nes-cre)1Wmz/0
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79917 )

• embyros die around E12.5

growth/size/body

decreased embryo size ( J:79917 )

• embryos are 80%-90% the size of wild-type littermates

nervous system

abnormal neural tube morphology ( J:79917 )

• thinned neural tube from the most rostral telencephalon to caudal spinal cord, including optic discs

abnormal embryonic neuroepithelium morphology ( J:79917 )

• frequent buckling of the surface

decreased embryonic neuroepithelium thickness ( J:79917 )

• the neuroepithelium is only one-quarter to one-half the thickness of that in control littermates

decreased neuronal precursor cell number ( J:79917 )

• severe neural progenitor cell loss

embryo

decreased embryo size ( J:79917 )

• embryos are 80%-90% the size of wild-type littermates

abnormal neural tube morphology ( J:79917 )

• thinned neural tube from the most rostral telencephalon to caudal spinal cord, including optic discs

abnormal embryonic neuroepithelium morphology ( J:79917 )

• frequent buckling of the surface

decreased embryonic neuroepithelium thickness ( J:79917 )

• the neuroepithelium is only one-quarter to one-half the thickness of that in control littermates