Phenotypes Associated with This Genotype

Genotype
MGI:2450979

• Allelic Composition: Met^tm1Cpo/Met^tm1Cpo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:36244 )

• embryonic death starts at E13.5

• no live embryos beyond E17.5

embryo

decreased embryo size ( J:36244 )

small placenta ( J:36244 )

pale placenta ( J:36244 )

growth/size/body

abnormal tongue muscle morphology ( J:36244 )

• tip of tongue lacked muscle

decreased embryo size ( J:36244 )

muscle

abnormal tongue muscle morphology ( J:36244 )

• tip of tongue lacked muscle

abnormal muscle development ( J:36244 )

• myotubes completely absent in forelimbs

absent diaphragm ( J:36244 )

• absent

craniofacial

abnormal tongue muscle morphology ( J:36244 )

• tip of tongue lacked muscle

digestive/alimentary system

abnormal tongue muscle morphology ( J:36244 )

• tip of tongue lacked muscle