Phenotypes Associated with This Genotype

Genotype
MGI:2450975

• Allelic Composition: Met^tm2Cpo/Met^tm2Cpo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:36244 )

• most animals die within a few hours after birth

growth/size/body

postnatal growth retardation ( J:36244 )

• animals surviving past postnatal day 1 display growth retardation during first week

limbs/digits/tail

abnormal forelimb morphology ( J:36244 )

• hyperflexed forelimbs

muscle

decreased skeletal muscle mass ( J:36244 )

• animals surviving past postnatal day 1 display reduced limb muscle mass

behavior/neurological

paraparesis ( J:36244 )

• hindlimb weakness