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Phenotypes Associated with This Genotype
Genotype
MGI:2450776
Allelic
Composition
Mmp20tm1Jdb/Mmp20tm1Jdb
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp20tm1Jdb mutation (2 available); any Mmp20 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Enamel delaminates from the dentin surface in Mmp20tm1Jdb/Mmp20tm1Jdb mouse molars

skeleton
• during enamel development, ameloblasts become progressively more disorganized
• disorganized enamel protein structure
• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel
• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

craniofacial
• during enamel development, ameloblasts become progressively more disorganized
• disorganized enamel protein structure
• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel
• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

growth/size/body
• during enamel development, ameloblasts become progressively more disorganized
• disorganized enamel protein structure
• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel
• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amelogenesis imperfecta hypomaturation type 2A2 DOID:0110060 OMIM:612529
J:80925


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory