Analysis Tools
mortality/aging
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• females show a rapid decline of ovarian function starting in early postnatal life, with signs of premature follicle loss at 9 weeks and complete follicle depletion by 16 weeks of age
• at 12 weeks, hemorrhagic ovarian cysts become evident, and many fragmented oocytes are seen in degenerating follicles
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reproductive system
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• ovulated eggs obtained from mated females fail to divide in vitro
(J:71679)
• young females display fragmented oocytes, poor oocyte quality, and gene expression profiles consistent with advanced oocyte age
(J:156655)
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• females show progressive and rapid loss of maturing oocytes; ovaries contain very few oocytes by 10 weeks of age and are completely devoid of oocytes at 17 weeks of age
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• after treatment with estrogen, ovaries from 3-4-week-old females show increased granulosa cell apoptosis in preantral follicles, as determined by activated caspase 3 immunostaining and TUNEL assays
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• granulosa cells show significantly impaired ability to proliferate in response to multiple hormonal stimuli in vivo, including exogenous stimulation with estrogen or PMSG or endogenously increased FSH levels
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• at 3, 6 and 12 weeks of age, numbers of primordial follicles are significantly lower than in controls
• however, numbers of primary follicles are not significantly altered, suggesting normal recruitment of the primordial follicles into the growing phase
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• at 3 and 12 weeks of age, numbers of preantral follicles are significantly lower than in controls
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• antral follicles gradually increase in number up to 6 weeks of age, but decline at 12 weeks due to depletion in the primordial and growing oocyte reserves
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• at 3 weeks of age, numbers of antral follicles are significantly lower than in controls
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• at 17 weeks of age, ovaries are completely devoid of all developing follicles
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• at 3 and 6 weeks of age, ovarian follicles show a trend towards increased numbers of atretic follicles
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(J:71679)
• multiple aspects of folliculogenesis are affected with defects in early primordial follicle survival as well as subsequent follicle growth
(J:119191)
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small ovary
(
J:71679
)
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• starting at 16 weeks of age, ovaries contain one or more hemorrhagic ovarian cysts
• hemorrhagic cysts are regularly observed at 20 weeks and beyond
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• by 12 weeks, many fragmented oocytes are seen in degenerating follicles
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• females show a rapid decline of ovarian function starting in early postnatal life, with signs of premature follicle loss at 9 weeks and complete follicle depletion by 16 weeks of age
• at 12 weeks, hemorrhagic ovarian cysts become evident, and many fragmented oocytes are seen in degenerating follicles
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• in female mice, age at onset of puberty (entry onto estrus) is 24.5 +/- 1.3 days versus 29.8 +/- 0.5 days for wild-type females
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• 2-month-old females fail to undergo induced ovulation whereas 5- to 6-month-old females respond poorly to hormone treatment
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• females prematurely enter and exit the estrous cycle; females enter persistent estrus at 50 +/- 1.5 days, whereas wild-type controls do not enter until ~465 days (15 months)
• window of normal cycling is small from an early onset at 24.5 +/- 1.3 days to a state of persistent estrus starting at 50 +/- 1.5 days
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• older females spend the vast majority of time in estrus with sporadic and brief reentry into the estrous cycle
• females do not remain in estrus for periods of >3 days until 6-7 weeks of age, with persistent estrus occurring at 50 +/- 1.5 days
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• females are infertile putatively due to impaired oocyte maturation and/or fertilization
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cellular
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• ovulated eggs obtained from mated females fail to divide in vitro
(J:71679)
• young females display fragmented oocytes, poor oocyte quality, and gene expression profiles consistent with advanced oocyte age
(J:156655)
|
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• females show progressive and rapid loss of maturing oocytes; ovaries contain very few oocytes by 10 weeks of age and are completely devoid of oocytes at 17 weeks of age
|
|
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• after treatment with estrogen, ovaries from 3-4-week-old females show increased granulosa cell apoptosis in preantral follicles, as determined by activated caspase 3 immunostaining and TUNEL assays
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• granulosa cells show significantly impaired ability to proliferate in response to multiple hormonal stimuli in vivo, including exogenous stimulation with estrogen or PMSG or endogenously increased FSH levels
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homeostasis/metabolism
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• females exhibit high serum FSH levels as early as 3 weeks of age
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growth/size/body
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• starting at 16 weeks of age, ovaries contain one or more hemorrhagic ovarian cysts
• hemorrhagic cysts are regularly observed at 20 weeks and beyond
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endocrine/exocrine glands
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• after treatment with estrogen, ovaries from 3-4-week-old females show increased granulosa cell apoptosis in preantral follicles, as determined by activated caspase 3 immunostaining and TUNEL assays
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• granulosa cells show significantly impaired ability to proliferate in response to multiple hormonal stimuli in vivo, including exogenous stimulation with estrogen or PMSG or endogenously increased FSH levels
|
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• at 3, 6 and 12 weeks of age, numbers of primordial follicles are significantly lower than in controls
• however, numbers of primary follicles are not significantly altered, suggesting normal recruitment of the primordial follicles into the growing phase
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• at 3 and 12 weeks of age, numbers of preantral follicles are significantly lower than in controls
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• antral follicles gradually increase in number up to 6 weeks of age, but decline at 12 weeks due to depletion in the primordial and growing oocyte reserves
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• at 3 weeks of age, numbers of antral follicles are significantly lower than in controls
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• at 17 weeks of age, ovaries are completely devoid of all developing follicles
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• at 3 and 6 weeks of age, ovarian follicles show a trend towards increased numbers of atretic follicles
|
|
|
(J:71679)
• multiple aspects of folliculogenesis are affected with defects in early primordial follicle survival as well as subsequent follicle growth
(J:119191)
|
small ovary
(
J:71679
)
|
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• starting at 16 weeks of age, ovaries contain one or more hemorrhagic ovarian cysts
• hemorrhagic cysts are regularly observed at 20 weeks and beyond
|
|
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• by 12 weeks, many fragmented oocytes are seen in degenerating follicles
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• females show a rapid decline of ovarian function starting in early postnatal life, with signs of premature follicle loss at 9 weeks and complete follicle depletion by 16 weeks of age
• at 12 weeks, hemorrhagic ovarian cysts become evident, and many fragmented oocytes are seen in degenerating follicles
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