Phenotypes Associated with This Genotype

Genotype
MGI:2450724

• Allelic Composition: Abca1^tm1Jdm/Abca1⁺
• Genetic Background: DBA/1LacJ-Abca1^tm1Jdm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:61679 )

• low apolipoprotein A-I level, reduced relative to wild-type on chow and Western-type diets

• low apolipoprotein B level, 20% reduction on chow diet

decreased circulating cholesterol level ( J:61679 )

decreased circulating HDL cholesterol level ( J:61679 )

• reduced relative to wild-type on chow and Western-type diets

decreased circulating LDL cholesterol level ( J:61679 )

• 20% reduction on chow diet

abnormal circulating phospholipid level ( J:61679 )

respiratory system

abnormal lung morphology ( J:61679 )

• microscopic, but not macroscopic, pale foci observed

• foci consisted of type II pneumocytes, lipid-laden macrophages, and cholesterol clefts