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Phenotypes Associated with This Genotype
Genotype
MGI:2450673
Allelic
Composition
Abca1tm1Wpfl/Abca1tm1Wpfl
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Wpfl mutation (0 available); any Abca1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced number of pups surviving until weaning at 3 weeks (J:64390)
• many pups dead by 2 days afer birth (J:64390)
• reduced number of pups surviving until weaning at 3 weeks (J:64390)
• many pups dead by 2 days afer birth (J:64390)
• resorption and fetal death observed at E14 (J:64390)
• resorption and fetal death observed at E14 (J:64390)

cardiovascular system
• observed in adult mice exhibiting respiratory distress (J:64390)
• observed in adult mice exhibiting respiratory distress (J:64390)

digestive/alimentary system
• increased fecal excretion of endogenously synthesized sterols (J:68431)
• increased fecal excretion of endogenously synthesized sterols (J:68431)

embryogenesis
• disrupted architecture with hemorrhages, cell debris, and inclusions of spongiotrophoblast (J:64390)
• distorted symmetry (J:64390)
• disrupted architecture with hemorrhages, cell debris, and inclusions of spongiotrophoblast (J:64390)
• distorted symmetry (J:64390)

endocrine/exocrine glands
• reduced cholesterol levels (J:64390)
• absence of cholesteryl esters (J:64390)
• absence of free cholesterol crystals in adrenal cortex (J:64390)
• reduced cholesterol levels (J:64390)
• absence of cholesteryl esters (J:64390)
• absence of free cholesterol crystals in adrenal cortex (J:64390)
• lipid depositions in medulla, particularly where medulla borders cortex (J:64390)
• lipid depositions in medulla, particularly where medulla borders cortex (J:64390)
(J:64390)
(J:64390)
• abnormal lipid deposition in Sertoli cells (J:64390)
• abnormal lipid deposition in Sertoli cells (J:64390)

growth/size/body
• those that survived, were runted by 2.5 weeks after birth (J:64390)
• those that survived, were runted by 2.5 weeks after birth (J:64390)

homeostasis/metabolism
• increased fecal excretion of endogenously synthesized sterols (J:68431)
• increased fecal excretion of endogenously synthesized sterols (J:68431)
• 62.8% reduction in serum levels of estrogen relative to wild-type (J:64390)
• 62.8% reduction in serum levels of estrogen relative to wild-type (J:64390)
• 53% reduction in serum levels of progesterone relative to wild-type (J:64390)
• 53% reduction in serum levels of progesterone relative to wild-type (J:64390)
• reduced by ~80% from wild-type levels (J:64390)
• reduced by ~80% from wild-type levels (J:64390)
• markedly reduced (J:68431)
• markedly reduced (J:68431)
• minimal amounts detected (J:64390)
• minimal amounts detected (J:64390)
• nearly completely absent (J:68431)
• nearly completely absent (J:68431)

immune system
• lipid depositions in medulla, particularly where medulla borders cortex (J:64390)
• lipid depositions in medulla, particularly where medulla borders cortex (J:64390)
• deposition of immunoglobulin and complement components, indicative of glomerulonephritis type I (J:64390)
• deposition of immunoglobulin and complement components, indicative of glomerulonephritis type I (J:64390)
• inflammation of the uterus, accompanied by thick green-brown mucous (J:64390)
• inflammation of the uterus, accompanied by thick green-brown mucous (J:64390)

liver/biliary system
• depositions in large vacuoles throughout liver (J:64390)
• depositions in large vacuoles throughout liver (J:64390)

muscle
• observed in adult mice exhibiting respiratory distress (J:64390)
• observed in adult mice exhibiting respiratory distress (J:64390)

renal/urinary system
• deposition of immunoglobulin and complement components, indicative of glomerulonephritis type I (J:64390)
• deposition of immunoglobulin and complement components, indicative of glomerulonephritis type I (J:64390)
• scarred glomeruli (J:64390)
• scarred glomeruli (J:64390)

reproductive system
(J:64390)
(J:64390)
• abnormal lipid deposition in Sertoli cells (J:64390)
• abnormal lipid deposition in Sertoli cells (J:64390)
• inflammation of the uterus, accompanied by thick green-brown mucous (J:64390)
• inflammation of the uterus, accompanied by thick green-brown mucous (J:64390)
• multiple resorptions, runts, dead fetuses found at E14 (J:64390)
• multiple resorptions, runts, dead fetuses found at E14 (J:64390)
• 55% fewer pregnancies after mating than wild-type (J:64390)
• 55% fewer pregnancies after mating than wild-type (J:64390)

respiratory system
• necropsy of wasted pups showed bronchopulmonary dysplasia, indicative of respiratory distress (J:64390)
• mice that survived past weaning exhibited respiratory distress at 4 to 6 months (J:64390)
• necropsy of wasted pups showed bronchopulmonary dysplasia, indicative of respiratory distress (J:64390)
• mice that survived past weaning exhibited respiratory distress at 4 to 6 months (J:64390)

hematopoietic system
• lipid depositions in medulla, particularly where medulla borders cortex (J:64390)
• lipid depositions in medulla, particularly where medulla borders cortex (J:64390)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory